: Problem 12 A non-obese male patient (35 years, 73kg) is to be given an infusion of ampicillin trihydrate for a respiratory infection. His specific kidney function is not known, but is thought to be normal. The distribution volume of the drug is 0.28 L kg-¹ and the elimination half-life is 1.3 hours. The desired therapeutic concentration range for the drug is considered to be 10-50 micrograms mL-¹. a. Calculate the loading dose in milligrams for the ampicillin trihydrate to achieve a concentration of mid-way in the desired range. (Hint, see equation 9.3 in the Study Guide.) b. Calculate the infusion rate to achieve the mid-way concentration as the steady- state concentration. C. If it is considered reasonable for a patient to receive a total daily dose of ampicillin trihydrate of 150mg kg-¹, would the regimen determined above be likely to be safe on the first day? d. What would be the total amount infused on the second day?
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